Bellus Health

Pipeline

BLU-5937

BLU-5937

BLU-5937

BLU-5937 is a potent P2X3 receptor antagonist with high selectivity for P2X3 (>1500 fold) over P2X2/3. In healthy volunteers, BLU-5937 showed good drug and pharmacokinetic characteristics.1   

Bellus Health is currently developing BLU-5937 for the treatment of refractory chronic cough, a condition with a high unmet medical need and a significant market opportunity.

Program Development Status
Indication/ProjectInd/Proj
PreclinicalPre
Phase 1Ph1
Phase 2Ph2
Phase 3Ph3
Worldwide RightsRights
Next Anticipated MilestoneNext

BLU-5937

BLU-5937

Refractory
Chronic Cough
(BID Formulation)
Bellus Health logo

June 2022: FDA End of Phase 2 Meeting
2H 2022: Start of Phase 3 Program

Refractory
Chronic Cough
(QD Formulation)
Refractory
Chronic Cough
(QD Formulation)
Bellus Health logo

2H 2022: Start of Phase 1

References

1. Garceau et al. Am. J. Resp Crit Care Med. 2019 199 A7395 P556.

clinicaltrials.gov

Refractory Chronic Cough

Chronic cough is a cough lasting longer than eight weeks and may affect up to 10% of the global population.1 When the cause of chronic cough cannot be identified or the cough persists despite treatment of all identified associated causes, the condition is referred to as refractory chronic cough. Refractory chronic cough can cause significant physical, psychological, and social burdens.2 There is no therapy approved to date for refractory chronic cough.

Next Steps

BELLUS recently announced positive topline results from the Phase 2b SOOTHE trial, highlighting BLU-5937’s best-in-class potential for the treatment of refractory chronic cough. The Company plans to initiate Phase 3 registration trials in 2H 2022.

References

1. Song et al. Eur Respir J. 2015 45(5):1479-81 2. Morice et al. 2014 Eur Resp J 44(5) 1132-48

BLU-5937 remains in development and has not been approved for commercialization. The clinical safety and effectiveness of BLU-5937 have not yet been fully established. The development of this product, and an investment in BELLUS Health common shares, involved a significant amount of risks. We invite you to review our Annual Information Form to learn more about these risks factors. A summary of these can also be reviewed here.