Bellus Health


Role of P2X3

Role of P2X3

Role of P2X3 in Neuronal Hypersensitization Disorders

P2X3 receptors play an important role in the sensitization of the nervous system to various stimuli.1 P2X2/3 receptors, closely related channels, also transmit sensory signals and may play a predominant role in taste, potentially causing taste alteration if inhibited.2 BLU-5937 is a potent P2X3 receptor antagonist with high selectivity for P2X3 (>1500 fold) over P2X2/3.3 Selective inhibition of P2X3 may help address hypersensitization disorders while limiting impact on taste.

BLU-5937 remains in development and has not been approved for commercialization. The clinical safety and effectiveness of BLU-5937 have not yet been fully established. The development of this product, and an investment in BELLUS Health common shares, involved a significant amount of risks. We invite you to review our Annual Information Form to learn more about these risks factors. A summary of these can also be reviewed here.

Examples of Cough And Other Conditions Potentially Associated with P2X3

  • Refractory Chronic Cough4
  • Cough Reflex Hypersensitivity During and Following Upper Respiratory Tract Viral Infections5
  • Cough Reflex Hypersensitivity Associated with Worse Clinical Outcome in Asthma6
  • Cough Reflex Hypersensitivity Observed in Idiopathic Pulmonary Fibrosis7
  • Endometriosis Pain8
  • Interstitial Cystitis9
  • Overactive Bladder10
  • Neuropathic Pain11
  • Migraine12
  • Inflammatory Bowel Syndrome13
  • Hypertension14

1. Ford et al. Front Cell Neurosci. 2013 7:267. 2.Finger et al. Science. 2005 310(5753):1495-9. 3. Garceau et al. Pulm Pharmacol Ther. 2019 56:56-62. 4. Abdulqawi et al Lancet. 2015 385(9974):1198-205. 5. Zaccone et al. (2016) Lung 194(1):25-9 6. Kanemitsu et al. (2020) Am J Respir Crit Care Med 201(9):1068-1077. 7. Hope-Gill et al.(2003) Am J Respir Crit Care Med 168: 995–1002 8. Trapero et al. Int J Mol Sci. 2020 21(22):8512. 9. Chai et al. J Urol. 2004 171(1):448-52.  10. Gao et al. Nat Commun. 2015 6:7650. 11. Inoue et al. Biochem Pharmacol. 2021 187:114309. 12. Giniatullin et al. Mol Neurobiol. 2008 37(1):83-90. 13. Deiteren et al. PLoS One. 2015 10(4):e0123810. 14. Pijacka et al. Nat Med. 2016 22(10):1151-1159.