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Role of P2X3

Role of P2X3

Role of P2X3 in Neuronal Hypersensitization Disorders

P2X3 receptors play an important role in the sensitization of the nervous system to various stimuli.1 P2X2/3 receptors, closely related channels, also transmit sensory signals and may play a predominant role in taste, potentially causing taste alteration if inhibited.2 BLU-5937 is a potent P2X3 receptor antagonist with high selectivity for P2X3 (>1500 fold) over P2X2/3.3 Selective inhibition of P2X3 may help address hypersensitization disorders while limiting impact on taste.

BLU-5937 remains in development and has not been approved for commercialization. The clinical safety and effectiveness of BLU-5937 have not yet been fully established. The development of this product, and an investment in BELLUS Health common shares, involved a significant amount of risks. We invite you to review our Annual Information Form to learn more about these risks factors. A summary of these can also be reviewed here.

Examples of Cough And Other Conditions Potentially Associated with P2X3

  • Refractory Chronic Cough4
  • Cough Reflex Hypersensitivity During and Following Upper Respiratory Tract Viral Infections5
  • Cough Reflex Hypersensitivity Associated with Worse Clinical Outcome in Asthma6
  • Cough Reflex Hypersensitivity Observed in Idiopathic Pulmonary Fibrosis7
  • Endometriosis Pain8
  • Interstitial Cystitis9
  • Overactive Bladder10
  • Neuropathic Pain11
  • Migraine12
  • Inflammatory Bowel Syndrome13
  • Hypertension14
References

1. Ford et al. Front Cell Neurosci. 2013 7:267. 2.Finger et al. Science. 2005 310(5753):1495-9. 3. Garceau et al. Pulm Pharmacol Ther. 2019 56:56-62. 4. Abdulqawi et al Lancet. 2015 385(9974):1198-205. 5. Zaccone et al. (2016) Lung 194(1):25-9 6. Kanemitsu et al. (2020) Am J Respir Crit Care Med 201(9):1068-1077. 7. Hope-Gill et al.(2003) Am J Respir Crit Care Med 168: 995–1002 8. Trapero et al. Int J Mol Sci. 2020 21(22):8512. 9. Chai et al. J Urol. 2004 171(1):448-52.  10. Gao et al. Nat Commun. 2015 6:7650. 11. Inoue et al. Biochem Pharmacol. 2021 187:114309. 12. Giniatullin et al. Mol Neurobiol. 2008 37(1):83-90. 13. Deiteren et al. PLoS One. 2015 10(4):e0123810. 14. Pijacka et al. Nat Med. 2016 22(10):1151-1159.