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BELLUS Health is a clinical stage biotechnology company focused on developing a P2X3 antagonist to address refractory chronic cough and other hypersensitization disorders. The Company’s lead candidate, BLU-5937, is a highly selective P2X3 antagonist currently being developed for the treatment of refractory chronic cough. The Company has initiated the CALM Phase 3 program, which consists of two pivotal trials CALM-1 and CALM-2.  BELLUS Health is also exploring how inhibition of P2X3 receptors can help treat other afferent hypersensitization-related disorders.

We invite you to visit our investors’ relations page, including our Annual Information Form, to obtain more information about BELLUS Health.

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P2X3 Receptors and Chronic Cough

P2X3 receptors are ion channels expressed on sensory nerves throughout the body and play an important role in the sensitization to various stimuli.1 P2X3-induced hypersensitization in the airways may result in an exaggerated urge to cough, refractory to the treatment of otherwise identifiable causes.2 Bellus Heath is investigating the P2X3 antagonist, BLU-5937, as a potential treatment for refractory chronic cough.